The thirteenth-generation Ford F-Series is a range of pickup trucks produced by Ford. Introduced for the 2015 model year, this generation of the F-Series is the first aluminum-intensive vehicle produced on a large scale by an American vehicle manufacturer. For the 2017 model year, the fourth-generation Super Duty line adopted the cab design of the F-150, consolidating the cab design for the first time on Ford light-duty trucks (F-550 and below) for the first time since the 1996 model year; the Super Duty trucks still retain separate bodywork and a higher-GVWR frame.

After a two-year hiatus, a second generation of the Ford Raptor made its return for 2017 as a high-performance variant of the F-150, dropping the SVT prefix). In Mexico, the F-Series XL trim is marketed as the F-150, XLT and higher trims are named Lobo (Wolf in Spanish). The Mexican-market Lincoln Mark LT was discontinued completely, replaced by the Limited and Platinum trims sold elsewhere.

The thirteenth-generation F-Series is produced by Ford in Claycomo, Missouri (Kansas City Assembly) alongside the Ford Transit van and at Dearborn, Michigan (Dearborn Truck Plant).

The thirteenth-generation F-Series was unveiled at the 2014 North American International Auto Show on January 13, 2014. A number of safety technologies and driver assistance features were introduced as options, including: 360° camera, adaptive cruise control, collision warning with brake support, blind spot information system (BLIS) with cross-traffic alert, and a lane-keeping system.

While not the first aluminum-bodied vehicle developed by Ford (the company developed 40 aluminum-bodied Mercury Sable prototypes in 1993, reducing curb weight by 400 pounds), the F-Series was the first Ford aluminum-bodied vehicle to make it to production. While changing the metal composition of the best-selling vehicle in the United States, 85% of the parts of the vehicle were domestically-sourced (as of 2016).

When the F-150 was equipped with the optional 2.7L EcoBoost V6 engine and two-wheel drive, it was able to comply with proposed future CAFE standards through 2024 without any modifications.

The 2019 F-150 truck has earned a five-star overall IIHS crash rating.